ABSTRACT
Introduction: The COVID-19 pandemic necessitated proliferation of telesimulation. This pedagogy may be useful in rural areas to increase procedural adoption and reduce healthcare disparities. Our aim was to determine the current status of surgical simulation education to retool rural practicing Urologists. Method(s): Literature search was performed with a trained librarian for PubMed, EMBASE and Web of Science. Title/ screening were performed to include all studies of surgical simulation involving rural surgical learners to identify simulation education opportunities for practicing rural Urologists. Data was then extracted: simulation event, skills focus, MERSQI score, type/number of learners, learner assessment and event evaluation. Result(s): Seven manuscripts met inclusion criteria. Most were published 2019-2020 and were cross sectional (5/7, 71%). Mean adjusted MERSQI score was 13 (range 6-15.5). A wide range of surgical skills were taught (incl. laparoscopy, cricothyroidotomy, chest tube insertion, damage control laparotomy), but no Urological surgical skills. Two articles described mobile simulation units for rural areas. A total of 232 learners were identified including 69 medical students. One fifth of rural learners were non-medical or non-physicians. Only one study involved faculty, who were general surgeons. Conclusion(s): Telesimulation education for practicing Urologists in rural areas is lacking. Current in-operating room telementoring for rural Urologists requires surgeons to travel and perform their first cases utilizing this new technique on patients. Telesimulation to teach Urological skills in rural areas of the US may increase dissemination of techniques with no patient risk and has significant potential to redress current healthcare disparities.
ABSTRACT
Objectives: A 14-year-old female patient presents with marked haemorrhagic, adherent crusting of the upper and lower lip and enoral vesicles and erosions. Two weeks before, she had suffered from a respiratory tract infection. She did not take antibiotics but ibuprofen. One week later, she described a swelling and crusting of the upper and lower lips. Urogenital mucosa was also erosive. There was no ocular involvement. Another week later, cocard-like single lesions with partly central blister formation developed. A flaccid blister of 15 mm in diameter was detected in the left ear helix. In total, there was a limited cutaneous involvement of <10% BSA. The girl was admitted to the paediatric clinic. Method(s): Due to mucocutaneous eruptions, bullous lesions and multimucosal involvement, we assumed a Steven-Johnson syndrome or reactive infectious mucocutaneous eruption (RIME). Intravenous rehydration and prophylactic administration of cefotaxime and aciclovir were given. She was balanced and given analgesia with novalgin. The recent increased intake of ibuprofen was discontinued. Local therapy included mometasone cream and serasept dressings. During the inpatient stay, the general condition stabilised and the skin efflorescence's showed a clear regression. Result(s): The microbiological smears for COVID-19, HSV, VZV, mycoplasma, and chlamydia were negative. Discussion(s): As adult classifications for blistering severe cutaneous adverse reactions are limited applicable in children, Ramien et al. proposed revised paediatric-focused clinical criteria 2021. They leave traditional definitions of EEM, SJS and TEN. But they distinguish erythema multiforme (EM) for classic targets with/without mucosal involvement, RIME for cases with mucosal predominance and a respiratory infection trigger, and drug-induced epidermal necrolysis (DEN) for cases caused by medications. (Ramien BJD 2021) There are no current guidelines for RIME therapy. A reasonable management approach includes symptomatic therapy, treatment of identifiable infectious triggers (if possible), consulting urologists, ophthalmologists and gynaecologists (if necessary), immunosuppression, and psychological support. (Ramien ClinExpDermatol 2021).
ABSTRACT
INTRODUCTION AND OBJECTIVE: Urologists are experiencing burnout at an alarming rate. With this, the American urologic Association (AUA) has continued to collect various pertinent workforce metrics in the annual census. Here the AUA Workforce Workgroup compares the latest data collected in the census related to burnout, comparing these metrics over time. METHOD(S): The AUA Workforce Workgroup examined the annual census results since 2016. The AUA sends out an annual census to all practicing urologists. The census works to collect demographic and geographic data, in addition to collecting answers to other pertinent questions from practicing urologists. Particular to this study, burnout related data was examined from the past 5 years. Examined metrics included burnout assess across age and gender, effect of COVID on burnout, work-personal life conflict across demographic groups. RESULT(S): In 2021, 36.7% of urologists report burnout compared to 36.2% in 2016. When assessing by gender, burnout in men decreased from 36.3% to 35.2%, but increased in women from 35.3% to 49.2%. When examined by age, the largest increases in burnout were seen in the<45 years old group, increasing from 37.9% to 44.8%, followed by 45-54 years old, 43.4% to 44.6%. Those over age 55 either had a decrease or stable burnout. When asked about the effect of COVID-19 on burnout, 54% of urologists didn't feel COVID-19 impacted burnout. When considering work-life conflicts, 25.0% of men and 4.6% of women reported no conflict between work and personal responsibilities, while 25.7% of men and 44.7% of women resolved conflicts in favor of work or were unable to resolve them. Respondents were then asked how satisfied they were with work-life balance, where 22.5% of men, and 37.1% of women responded dissatisfied. Similarly, 33.6% of males reported their work schedule does not leave enough time for personal/family life, compared to 57.5% of females. CONCLUSION(S): Overall, urologists have higher burnout now when compared to 2016. The gender discrepancy has vastly widened with women experiencing burnout at an increased rate compared to 2016, while burnout in men decreased. Burnout has increased the most in younger urologists, with the highest increase seen in those<45 years old. Further action is needed to substantiate the causes of burnout. (Figure Presented).
ABSTRACT
INTRODUCTION AND OBJECTIVE: COVID-19 led to paradigm shifts in telemedicine due to patient's fear of office visits and travel avoidance. With widespread cancellation of office visits and reduction of diagnostic biopsy procedures in men with elevated PSAs, the need for a non-invasive/non-DRE At Home Collection Kit for assessing risk of aggressive prostate cancer and to prioritize biopsy procedures became apparent. We adapted the existing ExoDx Prostate (EPI) office liquid biomarker kit into an At Home Collection Kit physician/ patient shared decisions for prostate biopsy. METHOD(S): A 2-stage program for an At Home Collection Testing Kit program for the ExoDx Test was initiated in April 2020 at the onset of the COVID-19 pandemic. The Phase 1 Pilot study (100 patients, 6 sites) was completed in June 2020. Based on the findings in the pilot, the program was streamlined based on feedback from physicians, patients, and office mangers before making it available in Phase 2 to all urologists in the US. The utilization of the At Home Collection Kits have been measured. RESULT(S): Extensive feedback from the pilot program led to improvements and streamlining before the Phase 2 rollout. As of October 31st, 2022, >30% of all the ExoDx Prostate Tests are At Home Collection Kits. EPI Score distributions are identical (mean 28.4 and 29.7), (median 23.0 and 24.7) in home or clinic sample collection respectively (Figure 1). CONCLUSION(S): The COVID-19 pandemic accelerated major shifts to telehealth and increased use of At Home Testing. The ExoDx Prostate (EPI) At Home Collection Kit was successfully developed and employed to help men (>50 years old) with elevated PSAs (2-10 ng/ml) considering initial or repeat diagnostic biopsy but with pandemic-related fears of visiting offices/hospitals or wanting to avoid long distance travel from rural areas. As COVID becomes manageable and clinical practices have opened, some pandemicadopted approaches remain relevant: the ExoDxTM Prostate, (EPI) At Home Collection Kit is one such approach.
ABSTRACT
INTRODUCTION AND OBJECTIVE: Infection control practices and public policy in response to the COVID-19 pandemic shifted healthcare practices towards a telemedicine format. Even two years after peak onset of the pandemic, many clinics, including our own institution, maintain a working telehealth option for patient visits, with some patients even preferring this modality of care delivery. Our objective was to evaluate patient utilization of telehealth visits versus inperson visits at our institution and whether this was impacted by demographics, medical history, and socioeconomic factors. METHOD(S): Medical Record Numbers for all patients with bladder cancer were pulled via accessible billing-level data from the period 7/1/2019-2/28/2022. Chart review was conducted to pull clinical data on patients including telehealth versus in person visits, demographic data, clinical stage, comorbidities (diabetes, smoking status, BMI), rural/urban status by zip code (>50,000, <50,000 individuals) and income levels by zip code (25K-49.9K, 50K-99.9K, <100K), payor status, patient distance, and gas savings/carbon footprint. RESULT(S): 430 patients completed in person visits while 268 completed telehealth visits. There was no statistically significant difference for in person visits vs. telehealth visits regarding patients' race (p=0.541), ethnicity (p=0.394) age (p=0.862), urban/rural status (p=0.507), payor status (p=0.127), mean zip code income (p=0.175), and comorbidities (p=0.626 for diabetes, p=0.706 for smoking, p=0.459 for BMI), and clinical stage (p=0.07). There was a statistically significant difference in mean distance (14.85 miles versus 26.86 miles, p<0.01). CONCLUSION(S): Post-pandemic, telehealth usage and acceptability among patients with bladder cancer remains high. Patients' with bladder cancer receive care from their urologist via in person visits versus telehealth at similar rates irrespective of their urban/rural status, demographics, payor status, relevant comorbidities, or relative income. Patients are more likely to engage in care with their urologist via telehealth if they live farther from a large urban academic center, which produces an economical and environmental impact via gas/time savings and reduced carbon footprint.
ABSTRACT
INTRODUCTION AND OBJECTIVE: Robotic assisted radical prostatectomy (RARP) is an invaluable whole gland treatment for intermediate, high-risk prostate cancer (PCa). However, a non-negligible proportion of these patients still harbour urinary incontinence and erectile disfunction after surgery. To assess the efficacy of our rehabilitation program in these patients. METHOD(S): A two arm, retrospective study on patients who underwent a RARP at a single institution in two pre-specified time intervals, namely March-July 2019 (study group) and March-July 2020 (control group), was conducted. Patients in the study group underwent a specific rehabilitation program, consisting of counseling with a prostate case-manager, an urologist and a physiotherapist, therefore starting pelvic floor muscle training (PFMT) at least 1-month before RARP. Due to the Covid-19 pandemic restrictions, this structured program was not delivered to the control group. The primary endpoint was the assessment functional outcomes at 30 days, 3 and 6 months after surgery. Continence recovery was defined as no use of pad, while erectile function (EF) recovery was defined as erection sufficient for an intercourse. Secondary endpoints included the following: surgical waiting time (SWT;period from prostate biopsy to surgery), biochemical recurrence (BCR) and/or imaging evidence of progression. RESULT(S): We included 249 patients, 136 (54.6%) in the study group and 113 (45.4%) in the control group. At 30 days after RARP, 49 (36.0%) patients in the study group were completely continent, and 6 (4.4%) had preserved EF as compared to 8 (7.1%) and 0 (0%) in the control group (p<0.001 and p=0.072 respectively). At 3 months, 131 (96.3%) were continent and 30 (22.1%) patients had recovery of EF in the study group, compared with 77 (68.14%) and 9 (8.0%) in the control group (p<0.001). Finally, at 6 months, 134 (98.5%) were continent and 50 (36.8%) had erection sufficient for intercourse in the study group, as compared with 96 (85.0%) and 19 (16.8%) in the control group (p<0.001). Median SWT was 2.9 (2.5-3.1) in 2019 and 5.8 (5.0-7.0) in 2020, (p<0.001). Median follow-up was 42 months (43-44) in the study group vs 32 (31-32) in the control group. No significant differences were observed in the proportion of patients experiencing BCR or imaging disease progression (8.1% vs 2.7%, p>=0.05). CONCLUSION(S): Our rehabilitation program is an valuable tool to enhance functional outcomes in patients undergoing RARP. Further prospective studies are still needed to confirm our results.
ABSTRACT
INTRODUCTION AND OBJECTIVE: Contemporary rates of burnout amongst urologists are reported to be 60-80%. These rates have significant implications on physician well-being and retention. We investigated predictors of burnout in female surgeons. METHOD(S): An electronic census survey was distributed to residents, fellows and practicing urologists by the Society of Women in Urology in the United States and territories via email and social media between February and May 2022. We assessed participant demographics, personal and professional characteristics, practice environment, compensation, and burnout with chi-square and t-test analyses. RESULT(S): There were 379 survey participants with an average age of 42 years (SD 10). A majority identified as cis-gendered heterosexual females (96%) and were practicing urologists (74%), while 10% were fellows and 15% residents/interns. Average reported time in practice was 9 years (SD 9 years). Most respondents reported burnout (273, 72%), with 87% agreeing COVID worsened burnout in the community. Those reporting burnout worked an average of 58 (SD 15) hours per week versus 49 (SD 18) hours (p<0.00001). Table 1 demonstrates significant personal and professional characteristics for participants who reported burnout. On multivariable logistic regression analysis, increased hours worked per week (OR 1.03, p=0.002), Relative Value Unit based pay versus salary (OR 4.4, p=0.007), correlated to burnout and feeling income is comparable to peers (OR 0.4, p=0.03) was inversely related. Common shared experiences included lack of staffing, reduced operating room time, lack of administrative support, predominance of non-operative referrals, gender and racial inequity or microaggressions, electronic health records with increased documentation demands, increased non-clinical administrative duties, and insufficient compensation or lack of financial advancement. CONCLUSION(S): A majority of women in urology report burnout with work-hours and compensation inequity as leading contributing factors. Concerns raised in this study such as lack of support staff, racial and gender inequity, and poor referral patterns should be further evaluated to determine a comprehensive plan to reduce burnout. (Figure Presented).
ABSTRACT
Introduction and Objectives: In late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as the cause of a cluster of pneumonia cases in China, and the corresponding disease was designated as Coronavirus Disease 2019 (COVID-19), spreading quickly around the world resulting in a pandemic. COVID-19 is associated with a set of coagulation abnormalities that increase the risk of thromboembolic events. Material(s) and Method(s): We report series of five cases of acute pulmonary thromboembolism following endourological procedures, treated in our tertiary care center, which after an apparent clinical improvement, developed acute pulmonary thrombo-embolism between second and third post-op day. Results and Observations: Among five cases, three were post PCNL and two post URSL. All Patients presented with dyspnoea, tachycardia, desaturation and hypotension. Further investigated with E.C.G, D-dimer, 2D-echo and CT-pulmonary angiogram, all suggestive of PTE. Hence patients were managed sucessfully in CCU with cardiologist advice and timely intrevention. Among five, three were managed with IV thrombolytic and anticoagulant therapy and two managed with IV anticoagulation alone , dose monitored with periodic coagulation profile. All patients discharged with oral newer anticoagulants and periodic follow up for 6 months. All patients on follow up and doing well. Conclusion(s): Thromboembolic events are potential complication of COVID-19 and can manifest later. Although very rare after endourological procedures, it requires high index of suspicion so as not to be missed as diagnosis, especially in hemodynamically unstable patients with respiratory distress. Early diagnosis and proper therapeutic actions is crucial for patients.
ABSTRACT
Introduction and Objective: Telemedicine is an established modality to deliver health care to patients remotely. Its role in pediatric urology followup among middle-class semi-urban families is unknown. We conducted a prospective observational questionnaire-based study to assess the patient and provider(urologist) satisfaction and feasibility of teleconsultation across different socioeconomic strata in follow-up of paediatric urology patients during the COVID 19 pandemic. Method(s): The guardians of children treated earlier and due for follow-up were explained and the appointment for teleconsultation was fixed using a video conferencing app. After consultation, consenting caregivers were explained about study and the provider survey was filled by consulting urologist, while the patient questionnaire was filled by principal investigator telephonically. Result(s): A total of 77 virtual visits were completed over 10 months. Median age was 8 years(IQR= 4 to 12) and 82% were boys. The clinical conditions were posterior urethral valves(22%), hypospadias(18%), PUJ obstruction(18%), vesicoureteric reflux(12%) and others(30%). Clinicians found that virtual visits were effective(78%) in deliverance of the care equivalent to the inpatient visit. Patients were equally satisfied(75%). Technical difficulties due to internet connectivity were faced in 24 visits(31%). Video clarity and inability to examine were additional limitations faced(23%). Majority(90%) belonged to the middle socioeconomic strata as per modified Kuppuswamy scale. Families were estimated to have saved a mean of 26,934 rupees(SD +- 7998.06) and a median of 7 days(Range 1-15) of travel time. Conclusion(s): Telemedicine has potential for successful follow-up with cost and time savings. With improving internet connectivity, its potential is likely to increase in future.
ABSTRACT
Introduction & Objectives: Robotic assisted radical prostatectomy (RARP) is an invaluable whole gland treatment for intermediate, high-risk prostate cancer (PCa). However, a non-negligible proportion of these patients still harbour urinary incontinence and erectile disfunction after surgery. To assess the efficacy of our rehabilitation program among patient with intermediate, high-risk PCa underwent RARP. Material(s) and Method(s): A two arm, retrospective study on patients who underwent a RARP at a single institution in two time intervals, namely March-July 2019 (study group) and March-July 2020 (control group), was conducted. Patients in the study group underwent a specific rehabilitation program, consisting of counseling with a prostate case-manager, an urologist and a physiotherapist, therefore starting pelvic floor muscle training (PFMT) at least 1-month before RARP. Due to the Covid-19 pandemic restrictions, this structured program was not delivered to the control group. The primary endpoint was the assessment functional outcomes at 30 days, 3 and 6 months after surgery. Continence recovery was defined as no use of pad, while erectile function (EF) recovery was defined as erection sufficient for an intercourse. Secondary endpoints included the following: surgical waiting time (SWT), defined as period from prostate biopsy to surgery and oncological outcomes, defined as biochemical recurrence (BCR) and/or imaging evidence of progression. Result(s): We included 249 patients, 136 (54.6%) in the study group and 113 (45.4%) in the control group. No significant differences in baseline characteristics, clinical and pathological features were observed between the two groups. At 30 days after RARP, 49 (36.0%) patients in the study group were completely continent, and 6 (4.4%) had preserved EF as compared to 8 (7.1%) and 0 (0%) in the control group (p <0.001 and p=0.072 respectively). At 3 months, 131 (96.3%) were fully continent and 30 (22.1%) patients had full recovery of EF in the study group, compared with 77 (68.14%) and 9 (8.0%) in the control group (p <0.001). Finally, at 6 months, 134 (98.5%) were continent and 50 (36.8%) had erection sufficient for intercourse in the study group, as compared with 96 (85.0%) and 19 (16.8%) in the control group (p <0.001). Median SWT was 2.9 (2.5-3.1) in 2019 and 5.8 (5.0-7.0) in 2020, (p<0.001). Median follow-up was 42 months (43-44) in the study group vs 32 (31-32) in the control group. No significant differences were observed in the proportion of patients experiencing BCR or disease progression between the two groups (8.1% vs 2.7%, p>=0.05). Conclusion(s): Our rehabilitation program appears to be a valuable tool to enhance functional outcomes in patients undergoing RARP. Further prospective studies on larger populations are still needed to confirm our results.Copyright © 2023 European Association of Urology. Published by Elsevier B.V. All rights reserved.
ABSTRACT
Case report - Introduction: This is the case of an adolescent referred to rheumatology following 5 years of back pain. After years of trying a number of treatments without much success, the cause was found to be a previously undiagnosed urological pathology. The case highlights awareness of non-rheumatological causes and incidental findings which can redirect a patient towards more appropriate treatment and reduce the potential for long-term adverse health issues and anxiety. Case report - Case description: B was referred age 16 to rheumatology with a 5-year history of lower back pain. She had previously seen paediatricians with symptoms initially attributed to constipation due to intermittent straining and hard stool. However, constipation remedies had not relieved the pain which progressed gradually to a more persistent dull ache with impact on daily activities. Various analgesics (including paracetamol and non-steroidal anti-inflammatories), exercises and acupuncture had not helped. There was no history of recurrent urinary tract infections or symptom correlation with fluid intake, menstruation or bowel habit. No inflammatory features or connective tissue disease symptoms were noted and family history was unremarkable Clinical examination was normal apart from mild tenderness in the lumbar region. Rheumatoid factor was borderline positive (15 iu/mL) with the rest of blood tests normal including renal function, inflammatory markers (CRP, ESR), anti CCP and ANA. She had minimal microscopic haematuria without proteinuria. MRI spine in 2015 was normal. In view of her young age and symptoms affecting daily activities, STIR sequence spinal MRI was requested. This excluded any new or old inflammatory changes but incidentally identified a dilated left pelvi-calyceal system. Renal ultrasound confirmed a grossly hydronephrotic left kidney with hydroureter and minimal renal tissue suggesting longstanding obstruction. No calculi were seen. The patient was referred to urologists. Further investigations (including MRI abdomen) confirmed similar findings and a distal ureteric stricture. A MAG 3 renogram showed a normal right kidney but only 12% functioning of the left kidney. Urologists have advised surgery (removal of left kidney and ureter) which may relieve symptoms or a conservative non-surgical approach (continue analgesia, physiotherapy and monitoring). The patient and her family are relieved to have a possible cause identified and are considering the surgical option due to ongoing flank discomfort. Case report - Discussion: This was an interesting finding of hydroureter and hydronephrosis causing longstanding back pain presenting to rheumatologists. Until completion of the spondyloarthropathy protocol MRI (STIR images), aetiology had been unclear. Hydronephrosis and hydroureter has no specific age or racial predilection. Signs and symptoms may depend on whether obstruction is acute/chronic. Chronic cases may be asymptomatic or present as a dull discomfort (like this case). Some cases may only present in adulthood with pain precipitated by fluid intake. Blood tests may show impaired kidney function. Post-mortem studies suggest 50% of people have at least one renal abnormality (e.g., renal cysts, duplex ureters) with autopsy series incidence of hydronephrosis reported as 3.1%. Causes include anatomical abnormalities such as vesico-ureteric reflux, urethral strictures (usually present in childhood), calculi, benign prostatic hyperplasia, or intrapelvic neoplasms, pregnancy and infections (e.g., TB). Sudden onset unilateral renomegaly was reported in one case of primary Sjogren's with lymphocytic interstitial nephritis and positive Sjogren's autoantibodies. Our patient has no clinical or serological evidence of connective tissue disease. Minor pelvi-calyceal distension can occur as a normal finding in wellhydrated patients and pregnancy. However, significant hydronephrosis requires assessment to determine cause as it may affect long term renal function. Imaging via computed tomography, ultrasound and urograms can help guide further management. In this case the preceding cause and duration of pathology is unknown. Sterile, giant hydronephrosis treatment options include observation and ureteric stent or nephrostomy in patients unfit for surgery. Nephrectomy is advised for pain and recurrent infection in a non-functioning kidney. Complications may include bowel perforation, vascular injury and urine leakage. Both open and minimally invasive procedures have good reported outcomes. The COVID-19 pandemic and exams have affected timing of any elective procedures and the patient understands surgery may or may not offer complete symptom resolution. Case report - Key learning points: . Non-inflammatory causes of back pain should always be considered in cases of persistent back pain, particularly in young people to ascertain if there is a treatable cause . Hydronephrosis cases can be asymptomatic or present with vague, intermittent, non-specific abdominal symptoms with normal physical examination with or without haematuria. This can cause diagnostic uncertainty and delay referral to urology and appropriate renal investigations . Assessment of renal function (including MAG 3 renogram) is important to guide further management . Surgical interventions (pyeloplasty/nephrectomy) may ease symptoms long term but there is no guarantee of a successful outcome and operative risks need to be considered too . Left undiagnosed, potentially this patient could have had further disruption to daily activities and both physical and mental well being.
ABSTRACT
Background: The utilization of virtual second opinions in oncology has increased considerably in the last decade, driven by the increased complexity of care and desire for expert opinion, improved technologies in telemedicine, and the acceleration of virtual services due to the Covid-19 pandemic. Therefore, it is important to further understand the patient populations that currently use virtual second opinion programs and to measure their effectiveness. Virtual second opinion programs provide a platform for patients to submit their medical history and questions regarding their condition to remote specialists who then render their opinions on diagnosis and management. Currently there is a paucity of research on the types of patient populations that seek second opinions and the outcomes of these rendered opinions. Here we describe the patient characteristics and changes in management associated with utilization of a virtual second opinion service at an academic medical center. Methods: In this IRB-approved retrospective review, we identified 657 cancer patients that utilized a virtual digital health platform to engage in second opinions at Stanford Healthcare. Patient demographics, cancer staging, site of origin, and prior therapeutic and surgical history were collected. Physician opinions rendered were self-classified into “major change in treatment”, “minor change in treatment”, or “no change in treatment.”. Results: The majority of patients who utilized the virtual second-opinion platform had a diagnosis late-stage cancer (with 77.2% at Stage III or IV). Breast cancer was the most common primary tumor site (24.7% of patients) followed by GI (21.9%) and GU malignancies (14.0%). Patients diagnosed with dermatological (4.4%), head and neck (3.3%), and neurological (3.2%) malignancies were least common. Physicians providing the virtual second-opinion were primarily medical oncologists (67.6%), followed by gynecologists (6.8%), urologists (5.2%), radiation oncologists (5.0%), and surgical oncologists (4.4%). Physicians self-reported that in more than half of cases reviewed (53.8%) a minor or major treatment change was recommended. Conclusions: This study showed that patients access second opinion platforms at late stage of cancer disease progression. With treatment changes recommended for more than half of the cases, virtual second opinion programs can potentially have a significant impact on cancer care. Patient satisfaction and clinical outcomes from virtual second opinion programs is an area of on-going research.
ABSTRACT
Background: Relugolix was approved by the FDA in late 2020 as an oral gonadotropin-releasing hormone (GnRH) receptor antagonist for the treatment of adults with advanced PCa. The approval was based on a large randomized trial (Shore et al NEJM) of patients with evidence of biochemical or clinical relapse after local primary intervention with curative intent (50%), newly diagnosed mCSPCa (23%), and advanced localized disease not suitable for primary surgical intervention with curative intent (28%). Our study aims to observe the adoption of relugolix in a large community-based medical oncology practice with affiliated urologists. Methods: A retrospective study using our EMR identified 39 males with PCa for whom relugolix was initiated between January 2021 and December 2021. The charts were analyzed for demographics, indications for treatment, barriers encountered to initiation of treatment, duration of therapy, previous therapies, specialty, primary insurance, and cardiovascular history. Results: Thirty-nine (39) patients with either localized PCa (40%) or with metastases to lymph nodes or distant sites (51%) were recommended initiation of relugolix by either urology (26%) or oncology (74%). Of these, 77% actually started the medication. 9 patients did not start therapy, of which 3 were due to insurance denial, 1 due to death, 2 changed their mind, and 3 did not start for unclear reasons. Medicare covered 56% of the patients. Cardiovascular disease was notable in 87%. 28% switched from another ADT due to intolerance, 10% started relugolix due to progressive disease, and 33% started as initial ADT. 13% discontinued within 6 months. Of these, 1 completed planned therapy, 3 were intolerant, 1 was switched to alternate therapy due to progression, and 1 had complications due to COVID. In comparison, 689 patients initiated ADT with leuprolide over the same time. Conclusions: ADT using GnRH agonists or antagonists form the backbone of PCa treatment, typically given as injections. The HERO trial showed that relugolix, a newer oral therapy, is associated with lower rates of cardiovascular events compared to leuprolide. While having at least one cardiovascular risk factor is a consideration for patients to either start with or switch to relugolix, the large majority of our patients still received first-line therapy with leuprolide. This study demonstrates limitations to initiating relugolix including financial constraints (e.g., insurance coverage), patient preference, and medication intolerance. (Table Presented).
ABSTRACT
Introduction: Klippel-Trenaunay syndrome (KTS) is a rare congenital vascular disease which is characterised by capillary, venous and lymphatic malformations. We describe the anaesthetic management of a 36 year old parturient with COVID-19 and KTS, who underwent an elective caesarean section. Very few such cases have been described and the multi-system nature of condition poses various challenges to both the obstetrician and the anaesthetist. Case Report: We had a 36-year-old woman who had experienced three previous normal vaginal deliveries and an elective caesarean section (CS) four years previously under general anaesthetic(GA) at 36 weeks gestation. She was told by a vascular surgeon that she was not suitable for regional anaesthesia. There was no recent imaging of her back to rule out arteriovenous(AV) malformations. Her past history included gastric bypass surgery under GA two years ago. She also had depression, varicose veins and three previous deep venous thrombosis andwas on prophylactic lowmolecularweight heparin. She had tested positive for COVID-19 4 days previously, and had mild symptoms of cough and sore throat. After a multi-disciplinary discussion involving an obstetrician, vascular surgeon, haematologist and anaesthetist, a decision was made to proceed with GA despite recent COVID-19, because of the possibility of AV malformations, in agreement with the patient. After securing two wide bore cannulae and adequate preoxygenation, a modified Rapid Sequence Induction was performed, and a tracheal tube was secured. Anaesthesia was maintained with oxygen, nitrous oxide and sevoflurane. After delivery of the baby, oxytocin 5U, followed by an infusion, midazolam, morphine, ondansetron and dexamethasone were administered. Extubation was performed when the patient was fully awake. In recovery, further opioids were given for pain. There were no concerns for the newborn. Estimated blood loss was 200 mL. Discussion: Gestation and its physiology may further exacerbate the manifestations of KTS, with increased obstetric risk. The success in the management of these patients requires the participation of a multidisciplinary team, consisting of obstetrician, anaesthetist, urologist, haematologist and vascular surgeon, with appropriate collaboration among the professionals involved. Periodic imaging and clotting tests are recommended to evaluate the evolution of vascular malformations in the pelvis, uterus and vagina, and identify neuraxial changes, to guide the safest way of delivery and anaesthesia.
ABSTRACT
Introduction & Objectives: The use of intra-operative image intensifier (II) has increased in urological practice as the mainstay of stone surgery is performed endoscopically. Here we examine the radiation exposure to the groin of the urologist performed endoscopic stone surgery. Our primary aim was to assess whether urologists are exposed to potentially avoidable radiation exposure in the seated position when using vest and skirt lead protection. We hypothesize that the level of exposure is negligible and should not influence surgeon decision on seated versus standing or on lead apron versus skirt and vest combination protective wear. Methods: We conducted a prospective, multicentre study across all public hospitals in the Hunter New England Area Health Network offering Holmium:YAG laser lithotripsy. Routinely, servicing a very large population base, the number of laser lithotripsy cases are quite high however during our research period the coronavirus pandemic diminished the number of elective cases performed. Because of this, we included a total of 50 cases in this study. Small multidimensional-reading dosimeters were worn on the medial aspect of both upper thighs of the urologist under the lead skirt as well as a third dosimeter worn on the outside of the lead protective skirt. All cases were performed with the II in an under-couch position and all cases included were either ureteroscopy or pyeloscopy with laser destruction of urinary stones. In one centre, all surgery was performed by a consultant urologist whilst in another it was all performed by a registrar. Screening time and total dose delivered were prospectively collected using the local network picture archiving and communication system (PACS). This data was analysed by an onsite physicist and collated. After calculating mean and median radiation dose exposures for each dosimeter and grouping those worn under the skirt, comparison was made between dosimeters worn under skirt versus over skirt and Results: Lead gowns reduced radiation dose exposure by 87% (p = <0.01);99% on the side opposite the II and by 76% on the same side of the II (p = 0.2). Mean total dose area product was 88.9 GyCm2 with a mean screening time of 80 seconds per case (range 12-311 seconds). Conclusions: These results support the hypothesis that there is no significant exposure risk in a seated position with vest and skirt combination lead protective wear. An unexpected result was the difference in exposure between the side closest versus furthest away from the image intensifier.
ABSTRACT
INTRODUCTION AND OBJECTIVE: Telemedicine use rapidly increased during the COVID-19 pandemic. However, the efficacy of telemedicine in the inpatient setting has yet to be addressed. To this end, we measured patient and provider satisfaction with video and faceto- face (FTF) consults for inpatient urology consultations and sought to identify the urologic conditions most suitable for video consults. METHODS: New inpatient urology consults between August 2021-October 2021 were randomized to either video or FTF consult. Patient surveys were administered within 24 hours to assess satisfaction and perceived quality of care during the consult (3-point ordinal Likert scale). Survey results were analyzed using Mann- Whitney U tests. Participating urology attendings completed a survey assessing satisfaction and utility of both consultation mediums (3- point ordinal Likert scale), and suitability of video consults for common urologic consultation conditions (5-point ordinal Likert scale). RESULTS: A total of 48 patients were included;23 (48%) received video consult and 25 (52%) FTF consults. There were no significant differences in age or race between the cohorts. The most common reasons for consultation were acute urinary retention (Video: 5 [22%], FTF: 5 [20%]) and urolithiasis (Video: 5 [25%], FTF: 3 [12%]). Both cohorts agreed that they were overall satisfied with their visit (Video: 22 [95.7%], FTF: 25 [100%];p=0.297), received high-quality care (Video: 22 [95.7%], FTF: 23 [92.0%];p=0.61), and would accept the visit modality again in the future (Video: 21 [91.3%], FTF: 25 [100%];p=0.14). Urologists agreed on the utility of both consultation mediums, including ability to gather complete information (Video: 7 [100%], FTF: 7 [100%]) and manage the patient (Video: 6 [85.7%], FTF: 7 [100%];p=0.71). Physician satisfaction was lower for video consult than FTF (Video: 5 [71.4%], FTF: 7 [100%];p=0.38), and physicians were less likely to agree that video consults were satisfactory compared to FTF visits (4 [57.1%]). The most suitable urologic conditions for video consultation were elevated PSA and urinary retention (4.85±0.38), followed by urinary incontinence and nephrolithiasis (4.71±0.49). The least suitable was scrotal wall swelling (2.71±0.76). CONCLUSIONS: With increasing telemedicine utilization, video consults offer an alternative to FTF rounding that may combat difficulties of urologist shortages. Video consults enable urologists to see a wide variety of inpatient consults without hindering patient satisfaction. However, adoption of this tool will rely on physician preference and competence with video technology.
ABSTRACT
INTRODUCTION AND OBJECTIVE: Like many global health organizations, International Volunteers in Urology (IVU) had to adjust to limitations on international travel during the COVID-19 pandemic that eliminated in-person surgical workshops. IVU turned to a completely virtual presence through the expansion of a visiting professorship program (VVP) of lectures given to international partner sites on requested topics via live video conference. These lectures were recorded and subsequently posted on YouTube, and promoted through social media, to increase accessibility. We reviewed the use of YouTube as an educational platform. METHODS: YouTube analytics of the IVU VVP program viewed after the live presentation from February 2020 through October 2021 were reviewed. We categorized the lectures by urology topic and evaluated them by the watch time in hours, the total number of views, and the number of channel subscribers. We then calculated an interest score, represented by the ratio of the number of views to the total number of videos under a specific topic, and a value score, represented by a ratio of total watch hours to the total number of videos. RESULTS: 68 lectures have been given over 20 months with 10,941 total views, 873.4 total hours of watch time, and 259 channel subscribers. The top three video categories by watch time and number of views included endourology (215.2 hours, 2,006 views), oncology (169.1 hours, 1,868 views), and pediatrics (164.9 hours, 3,453 views). “Ultrasound basics for urologists” was watched the most with 104.4 hours (1,000 views), while “Complex hypospadias” had the highest number of views at 1,200 (25.4 hours). The top three video categories by interest scores were endourology (287), pediatrics (247), and voiding dysfunction (189), while the top three by value scores were endourology (31), voiding dysfunction (18), and sexual health (15). For all videos, direct YouTube searches were the most common means of viewership (representing 41.7% of views), while external traffic sources represented 13.9% of views. Of the external traffic sources, the most common was from Google (14.2%). CONCLUSIONS: The COVID-19 pandemic led IVU to create a well-received VVP program, archived through YouTube to enable sustained remote education and outreach to international sites. Review of YouTube trends provided feedback on didactic topics. The difference in views and watch time highlight topics of higher educational value to international sites and may suggest areas of focus in future virtual and in-person didactics when they resume.
ABSTRACT
INTRODUCTION AND OBJECTIVE: Current evidence has proven the systemic nature of COVID19, including its involvement in the male reproductive tract. We aimed to investigate seminal parameters of moderate-to-severe COVID-19 men during the convalescence phase. METHODS: This cross-sectional study included 18 to 50-yearold men with confirmed moderate-to-severe COVID-19. Patients were enrolled 15 to 45 days after the diagnosis. After a urologist's initial clinical evaluation, semen samples were obtained by masturbation and processed within one hour. Semen analysis was performed using the World Health Organization (WHO) manual (6th edition). Sperm function tests were conducted in an andrology laboratory, including Reactive oxygen species (ROS), DNA fragmentation, lipid peroxidation, and Creatine Kinase (CK) analysis. An essential endocrine evaluation was performed. Patients with a history of disorders that could impair testicular function were excluded. A group of pre-vasectomy baseline samples was used as a control group. Statistical analysis was performed using R version 4.0.5. One-tailed and paired T-tests were used for comparisons between groups. RESULTS: The sample size was 26 men (mean 34.3±6.5 years;range: 21-50 years). Sperm concentration (mean 38.74±32, P <0.01) and total motile count (mean 55.3±66.8, P <0.01) were significantly reduced in the COVID-19 group. The DNA fragmentation (mean 41.1±29.2) and ROS (mean 4.84±8.7) were significantly higher in post-infection patients. Other parameters such as WHO/ Kruger morphology and progressive motility were also reduced in the disease group, albeit not statistically significant. Total testosterone (mean 409.2±201.2) was lower in the convalescent men. All semen samples were negative for SARS-CoV-2 using the PCR analysis. CONCLUSIONS: Our findings indicate that male reproductive injury can be a relevant component of SARS-CoV-2 systemic infection. High DNA fragmentation and ROS, hallmarks of tissue injury, might signal a direct testicular involvement. The morphological and functional damage could represent significant impairment of the male reproductive health if persistent after convalescence.
ABSTRACT
INTRODUCTION AND OBJECTIVE: The dramatic reduction of clinical and research activities within medicine during COVID-19, coupled with virtual electives and conferences, have all posed important implications within academics. Given the heavy reliance on virtual interaction during the pandemic and the active role that social media (SoMe) has, our study aims to characterize the state of SoMe use among current academic urology faculty. METHODS: We identified residency programs utilizing the American Urological Association (AUA) website. All MD/DO faculty information including gender, program location, and subspecialty training was recorded. After the designation of all faculty and their Twitter handles, Twitter Development API was set up with required authorizations and tokens. Python and R were used as the supporting language and setup using Anaconda Navigator. RESULTS: We identified 143 residency programs with a total of 2,377 faculty (1,975 males and 402 females). Among all faculty, 945 (39.75%) had registered Twitter accounts with the majority being male =760 (80.40%) vs 185 (19.60%)] (Figure 1a). Proportionately, female urologists were more likely to have a registered Twitter account (Figure 1a). Differences among specialty and SoMe use were also evident, with oncology (48%) and endourology (47.24%) among male faculty representing the highest registered user accounts (Figure 1b). When assessing registered accounts by gender across all faculty, there was no notable change during COVID (2019-2020), with peak for male faculty in 2014 (10.05% of all accounts registered) and peak for female faculty in 2015 (Figure 1c). The top five hashtags by occurrence were #prostatecancer, #urology, #bladdercancer, #covid19, and #aua19 among males, female faculty extending #sexmed as an additional common hashtag. When assessing faculty representation on Twitter, The University of Colorado (69.57%), Mayo Clinic Rochester (67.86%), and Case Western Reserve (65.22%) had the most represented faculty on SoMe proportional to the size of their program (Figure 1d). CONCLUSIONS: There is a steady increase in Twitter representation among academic urology, largely unaffected by COVID. While the majority of Twitter representation is largely skewed toward male faculty, there has been a steady increase in female faculty representation across all subspecialties over the last 16 years.
ABSTRACT
INTRODUCTION AND OBJECTIVE: Distancing requirements, supply chain issues, and social anxieties have resulted in restricted clinic interactions and reduced operative volumes. Introduction of telehealth (IOT) allowed access through virtual platforms, with retroactive coverage to March 1, 2020. Data suggests changing attitudes toward work hours, staffing shortages, and varied emotions to telehealth (TH) among patients and providers. We sought to determine trends in volume and complexity of clinical visits per provider for a university-based urology practice. METHODS: The CDC COVID Data Tracker was used to trend COVID cases/month statewide (NC), from the first case (March, 2020) to September, 2021. Outpatient clinic billing data for our practice was drawn for the same interval, as well as the preceding six months, and analyzed within three separate periods: (A) Pre-COVID (9/2019-2/ 2020), (B) Initial phase (3/2020-8/2020), and (C) First peak (9/2020-3/ 2021). We extracted E&M codes: 99203-99205, 99213-99215, TH codes 99442-99443, and GT/95 modifiers. 99442 and 99443 were walked over to 99213 and 99214, respectively, as per CMS. Mean monthly visits per provider (MVP) were determined. RESULTS: From A to B, MVP decreased significantly for inperson (IP) 99203, 99205, 99213 and 99024. However, with IOT, total MVP for 99214 significantly increased (55.5 vs 43.3, p=0.017), and recovered for 99203, 99204, and 99215. Relative to B, C had significantly increased IP MVP for all codes except 99214 and 99024, and TH use decreased significantly for all codes. Relative A, C had significant increases for 99204 (18.0 vs 12.9, p=0.001), 99214 (50.2 vs 43.3, p=0.022), 99215 (14.1 vs 12.5, p=0.024), while 99213 visits did not recover (44.1 vs 50.4, p=0.009);total monthly visits were higher but not significant (p=0.201). CONCLUSIONS: Although in-person visits decreased in the initial phase of the pandemic, clinical volumes recovered during the first COVID peak, with some changes in E&M distribution. The data suggests that IOT allowed improved delivery of care in terms of total visits. Research regarding change in effort distribution is needed. Preservation of TH appears warranted. (Figure Presented).